|1-((6R,7R)-7-((Z)-2-(2-氨基噻唑-4-基)-2-(甲氧基亚氨基)乙酰胺基)-2-羧基-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-3-基)甲基)-1-甲基吡咯烷-1-氯化铵盐酸盐水合物|CsnPharm

CAS No.: 123171-59-5

盐酸头孢吡肟一水合物 Catalog No. CSN10570

Synonyms: Cefepime (hydrochloride hydrate);Maxipime 2HCl;Cefepime Hydrochloride

Cefepime 2HCl H2O is a fourth-generation cephalosporin antibiotic with an extended spectrum of activity against Gram-positive and Gram-negative bacteria and greater activity against both types of organism than third-generation agents.

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技术信息

生物活性

描述Cefepime (Dihydrochloride Monohydrate) is a broad-spectrum cephalosporin with enhanced coverage against Gram-positive and Gram-negative bacteria. Cefepime has a high affinity for penicillin-binding proteins and, due to its zwitterionic configuration, rapidly penetrates outer-membrane porin channels of bacteria. Cefepime has a decreased propensity to induce beta-lactamases compared with other beta-lactam antibiotics. Cefepime has demonstrated clinical efficacy against a variety of infections, including urinary tract infections, pneumonia, and skin and skin structure infections and it is generally well tolerated^[3]. Cefepime should be avoided for empiric treatment of suspected ESBL (extended-spectrum beta-lactamase) infections and should only be considered for definitive treatment if the MIC (minimum inhibitory concentration) ≤ 1 µg/mL^[4].
参考文献

[1] Neu, H.C., Safety of cefepime: a new extended-spectrum parenteral cephalosporin. Am J Med, 1996. 100(6A): p. 68S-75S.
[2] Wynd MA, Paladino JA. Cefepime: a fourth-generation parenteral cephalosporin. Ann Pharmacother. 1996 Dec;30(12):1414-24.
[3] Wynd MA, Paladino JA. Cefepime: a fourth-generation parenteral cephalosporin. Ann Pharmacother. 1996 Dec;30(12):1414-24.
[4] Patel HB, Lusk KA, Cota JM. The Role of Cefepime in the Treatment of Extended-Spectrum Beta-Lactamase Infections. J Pharm Pract. 2019 Aug;32(4):458-463.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7498 mL
- 8.7489 mL
- 17.4979 mL
- 5 mM
- 0.3500 mL
- 1.7498 mL
- 3.4996 mL
- 10 mM
- 0.1750 mL
- 0.8749 mL
- 1.7498 mL

技术信息

CAS号

123171-59-5

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H28Cl2N6O6S2

运输

蓝冰

分子量

571.50

别名

Cefepime (hydrochloride hydrate);Maxipime 2HCl;Cefepime Hydrochloride;Cefepime HCl;Cefepime hydrochloride monohydrate;Quadrocef;Elan;头孢吡肟 2HCl H2O

溶解度

DMSO	99.0 mg/mL (173.2 mM)
Ethanol	Insoluble

动物实验配方

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